抗生素
纳米材料
抗菌剂
纳米技术
化学
材料科学
有机化学
生物化学
作者
Zhenyu Xing,Jiusi Guo,Zihe Wu,Chao He,Liyun Wang,Mingru Bai,Xikui Liu,Bihui Zhu,Qiuyue Guan,Chong Cheng
出处
期刊:Small
[Wiley]
日期:2023-08-25
卷期号:19 (50)
被引量:7
标识
DOI:10.1002/smll.202303594
摘要
Abstract Bacterial infection continues to be an increasing global health problem with the most widely accepted treatment paradigms restricted to antibiotics. However, the overuse and misuse of antibiotics have triggered multidrug resistance of bacteria, frustrating therapeutic outcomes, and leading to higher mortality rates. Even worse, the tendency of bacteria to form biofilms on living and nonliving surfaces further increases the difficulty in confronting bacteria because the extracellular matrix can act as a robust barrier to prevent the penetration of antibiotics and resist environmental damage. As a result, the inability to eliminate bacteria and biofilms often leads to persistent infection, implant failure, and device damage. Therefore, it is of paramount importance to develop alternative antimicrobial agents while avoiding the generation of bacterial resistance to prevent the large‐scale growth of bacterial resistance. In recent years, nano‐antibacterial materials have played a vital role in the antibacterial field because of their excellent physical and chemical properties. This review focuses on new physicochemical antibacterial strategies and versatile antibacterial nanomaterials, especially the mechanism and types of 2D antibacterial nanomaterials. In addition, this advanced review provides guidance on the development direction of antibiotic‐free disinfections in the antibacterial field in the future.
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