孟德尔随机化
特应性皮炎
混淆
医学
因果关系(物理学)
观察研究
疾病
皮肤病科
内科学
遗传学
生物
基因型
遗传变异
基因
物理
量子力学
作者
Kareem G. Elhage,Allison Kranyak,Joy Q. Jin,Kathryn Haran,Riley K. Spencer,Payton Smith,Mitchell S. Davis,Marwa Hakimi,Tina Bhutani,Wilson Liao
标识
DOI:10.1016/j.jid.2023.10.016
摘要
Prior studies have found associations between atopic dermatitis (AD) and comorbidities, including depression, obesity, asthma, and allergic rhinitis. Although observational studies often cannot establish robust causality between potential risk factors and AD, Mendelian randomization minimizes confounding when exploring causality by relying on random allelic assortment at birth. In this study, we systematically reviewed 30 Mendelian randomization studies in AD. Body mass index, gut microbial flora, the IL-18 signaling pathway, and gastroesophageal reflux disease were among the causal factors for AD, whereas AD was causal for several medical conditions, including heart failure, rheumatoid arthritis, and conjunctivitis. These insights may improve preventive counseling in AD.
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