Venous plexus-associated lymphoid hubs support meningeal humoral immunity

脑膜 生发中心 生物 免疫系统 滤泡树突状细胞 淋巴系统 硬脑膜 病理 获得性免疫系统 硬脑膜静脉窦 免疫学 解剖 神经科学 B细胞 医学 抗原提呈细胞 T细胞 抗体 内科学 血栓形成
作者
Nágela Ghabdan Zanluqui,Zachary Fitzpatrick,Jared S. Rosenblum,Zewen Kelvin Tuong,Vikram Chandrashekhar,María Luciana Negro‐Demontel,Kieren Allinson,Panagiotis Mastorakos,Prashant Chittiboina,Dragan Maric,Danielle Donahue,John R. Ferdinand,Anaïs Portet,Ana Peñalver,Eleanor Gillman,Zhengping Zhuang,Menna R. Clatworthy,Dorian B. McGavern
出处
期刊:Journal of Immunology [The American Association of Immunologists]
卷期号:210 (1_Supplement): 76.23-76.23
标识
DOI:10.4049/jimmunol.210.supp.76.23
摘要

Abstract There is increasing interest in how immune cells in the meninges, the membranes that surround the brain and spinal cord, contribute to homeostasis and disease in the central nervous system. The outer layer of meninges, the dura mater, contains both innate and adaptive immune cells and functions as a site for B cell development. In this study, we identified previously undescribed lymphoid structures surrounding fenestrated venous plexi in the dura mater. We found the most elaborate immune organization, including lymphatic vessels, surrounding the rostral-rhinal confluence of sinuses. We termed this structure that interfaced with the skull bone marrow and a comparable venous plexus at the skull base, the rostral-rhinal venolymphatic hub. This hub emerged during development in mice at P8/9 before formation of the superior sagittal sinus. Single cell RNA sequencing demonstrated that rostral rhinal hub hosts a diverse array of resident innate and adaptive immune cells during steady state. Immune aggregates were also present in this structure during homeostasis and expanded with age or following challenge with systemic or nasal antigens. Following intranasal VSV infection, the rostral-rhinal hub supported local germinal center (GC) reactions consisting of T follicular helper cells as well as GC B cells that underwent proliferation, somatic hypermutation, class switch, and conversion into plasma cells locally. These data demonstrate lymphoid architecture around vascular plexi in the dura mater that can sample antigens and rapidly elaborate local humoral immune responses to protect the meninges and underlying brain parenchyma from pathogens. This research was supported by the intramural program of the National Institute of Neurological Disorders and Stroke, NIH
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xx关闭了xx文献求助
2秒前
liujinjin完成签到,获得积分20
3秒前
Skuld应助Dukeliang采纳,获得10
4秒前
4秒前
BEN发布了新的文献求助10
4秒前
晨一发布了新的文献求助10
4秒前
7秒前
二十八化生完成签到 ,获得积分10
8秒前
mercy发布了新的文献求助10
10秒前
10秒前
10秒前
隐形曼青应助韩哈哈采纳,获得10
10秒前
11秒前
彩色不评完成签到,获得积分10
12秒前
喜悦雪珊完成签到,获得积分10
13秒前
Coisini完成签到,获得积分10
14秒前
枫叶的脚步完成签到,获得积分10
14秒前
toptop应助Valky采纳,获得10
14秒前
英俊的铭应助阔达听寒采纳,获得10
14秒前
科研通AI2S应助此时留念采纳,获得10
15秒前
tang发布了新的文献求助10
15秒前
zwj003完成签到,获得积分10
16秒前
萧水白应助喜遇徐采纳,获得10
16秒前
雨季发布了新的文献求助10
16秒前
小马甲应助禾日青采纳,获得10
17秒前
Akim应助zxy采纳,获得10
17秒前
煤灰发布了新的文献求助30
19秒前
丘山完成签到,获得积分10
19秒前
yzm788695发布了新的文献求助10
19秒前
汉堡包应助yo1nang采纳,获得10
20秒前
20秒前
20秒前
希望天下0贩的0应助雨季采纳,获得10
22秒前
23秒前
23秒前
24秒前
科研通AI2S应助聪仔采纳,获得10
24秒前
24秒前
WWXWWX发布了新的文献求助10
25秒前
26秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
XAFS for Everyone 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3145115
求助须知:如何正确求助?哪些是违规求助? 2796489
关于积分的说明 7819996
捐赠科研通 2452771
什么是DOI,文献DOI怎么找? 1305202
科研通“疑难数据库(出版商)”最低求助积分说明 627448
版权声明 601449