Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood

前列腺癌 雄激素剥夺疗法 神经认知 医学 心情 痴呆 雄激素受体 恩扎鲁胺 肿瘤科 癌症 内科学 情绪障碍 认知 心理学 疾病 临床心理学 精神科 焦虑
作者
Allison B. Reiss,Shelly Gulkarov,Aaron Pinkhasov,Katie M. Sheehan,Ankita Srivastava,Joshua De Leon,Aaron E. Katz
出处
期刊:Medicina-lithuania [MDPI AG]
卷期号:60 (1): 77-77
标识
DOI:10.3390/medicina60010077
摘要

Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer’s disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs. A comparative analysis of prostate cancer patients undergoing ADT and Alzheimer patients identified over 30 shared genes, illustrating common ground for the mechanistic underpinning of the symptomatology. The purpose of this review was to investigate the effects of ADT on cognitive function, mood, and quality of life, as well as to analyze the relationship between ADT and Alzheimer’s disease. The evaluation of prostate cancer patient cognitive ability via neurocognitive testing is described. Future studies should further explore the connection among cognitive deficits, mood disturbances, and the physiological changes that occur when hormonal balance is altered.
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