肝星状细胞
四氯化碳
化学
多糖
四氯化碳
体内
蛋白激酶B
生物化学
PI3K/AKT/mTOR通路
肝纤维化
果聚糖
信号转导
纤维化
细胞生物学
药理学
生物
果糖
内分泌学
内科学
医学
生物技术
有机化学
作者
Xiaolan Dai,Zhenyun Du,Can Jin,Bixi Tang,Xia Chen,Xiaoqi Jing,Yu‐Mei Shen,Fei He,Shunchun Wang,Jia Li,Kan Ding,Yi Zang
标识
DOI:10.1016/j.carbpol.2023.121637
摘要
Studies have shown that terrestrial acidic polysaccharides containing carboxyl groups and seaweed sulfated polysaccharides have strong potential in anti-liver fibrosis. However, there is no investigation on the anti-liver fibrosis of fructan, a ubiquitous natural polysaccharide. The present study aimed to understand the effect of fructan in ameliorating carbon tetrachloride (CCl4)-induced liver fibrosis in mice. Here, an inulin-like fructan ABWW from Achyranthes bidentata Bl. was characterized by fructose enzymatic hydrolysis, methylation analysis, ESI-MS, and NMR. It was composed of →2)-β-d-Fruf-(1→ and →2)-β-d-Fruf-(1, 6→, terminated with →1)-α-d-Glcp and →2)-β-d-Fruf residues. The biological studies showed that ABWW could improve liver damage and liver fibrosis induced by CCl4in vivo and inhibit hepatic stellate cell (HSC) activation and migration in vitro. We further demonstrated that ABWW inhibited LX2 activation via suppressing the FAK/PI3K/AKT signaling pathway. Hence, ABWW might be a potential novel active compound for anti-fibrosis new drug development.
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