Intermolecular Interaction Between BODIPY and TPE Enhances Phototherapy

Abstract Fluoroborodipyrrole (BODIPY) and Tetraphenylethylene (TPE) are well‐known molecules in the realm of optical materials, celebrated for their exceptional properties. Recent research increasingly focuses on their combined use. In this study, a novel non‐synthetic method is taken to harness the synergistic therapeutic potential stemming from intermolecular interactions by employing nanoparticle encapsulation and core–shell structure. In vitro and in vivo experiments results show that the nanoparticles encapsulating BODIPY and TPE exhibit low cytotoxicity, efficient antitumor properties, and excellent visualization, achieving remarkable 1+1>2 effects. This innovative method not only provides high therapeutic efficacy, but also reduces time and economic costs, providing a novel perspective for exploring the combination of BODIPY and TPE as well as similar molecules in the field of optical materials.