Urine Albumin Measurements in Clinical Diagnostics

尿 蛋白尿 白蛋白 肾脏疾病 指南 医学 内科学 病理
作者
Jesse C. Seegmiller,Lorin M Bachmann
出处
期刊:Clinical Chemistry [Oxford University Press]
卷期号:70 (2): 382-391 被引量:3
标识
DOI:10.1093/clinchem/hvad174
摘要

Abstract Background Measurement of urine albumin is critical for diagnosis, risk classification, and monitoring of chronic kidney disease (CKD). Guidelines recommend clinical decision cutoffs for the urine albumin-to-creatinine ratio (ACR) of 30 and 300 mg/g (3 and 30 mg/mmol). However, differences among manufacturers’ routine urine albumin measurement procedures have been found to exceed 40%, suggesting CKD diagnosis and risk classification may vary depending upon the specific measurement procedure implemented in the laboratory. Content This review discusses urine albumin pathophysiology and clinical practice guideline recommendations for CKD. The review also provides recommendations for urine specimen collection and storage, and results reporting for the ACR. Recent advances in measurement techniques and development of reference systems intended to facilitate standardization of urine albumin measurements are reviewed. Summary Urine albumin is an important measurement procedure used for diagnosis, risk classification, and management of CKD. Urine albumin results should be reported as the ACR using quantitative measurement procedures. Random urine collections used for albuminuria screening should be followed by confirmation with first morning void collections to reduce variation and increase diagnostic accuracy for urine albumin measurement. Most measurement procedures utilize immunoturbidimetric or immunonephelometric techniques. However, results vary significantly among measurement procedures, potentially resulting in differences in classification or risk assessment for CKD. The National Institute for Standards and Technology (NIST) and other laboratories are developing reference systems, including liquid chromatography–tandem mass spectrometry candidate reference measurement procedures and reference materials, to enable standardization of routine measurement procedures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Vanff发布了新的文献求助30
刚刚
研友_VZG7GZ应助王七七采纳,获得10
刚刚
刚刚
小马甲应助Remote采纳,获得10
1秒前
在水一方应助Remote采纳,获得10
1秒前
哇哈哈发布了新的文献求助10
1秒前
大个应助Remote采纳,获得10
1秒前
在水一方应助Remote采纳,获得10
1秒前
充电宝应助Remote采纳,获得10
1秒前
笑点低的山柏完成签到,获得积分10
1秒前
lhy发布了新的文献求助10
1秒前
1秒前
1秒前
2秒前
神公子完成签到,获得积分10
3秒前
金刚经应助黄酒十二刀采纳,获得10
3秒前
3秒前
忧伤的听白完成签到,获得积分20
3秒前
快来和姐妹玩完成签到,获得积分10
3秒前
Yau完成签到,获得积分10
3秒前
布丁121完成签到 ,获得积分10
4秒前
4秒前
yb发布了新的文献求助10
4秒前
6秒前
6秒前
6秒前
6秒前
7秒前
caozhanbo发布了新的文献求助10
8秒前
月出完成签到,获得积分20
8秒前
9秒前
9秒前
KingXing发布了新的文献求助10
9秒前
Hello应助phil采纳,获得10
10秒前
汉堡包应助tusyuki采纳,获得10
10秒前
potato511发布了新的文献求助10
10秒前
10秒前
ZXY完成签到,获得积分10
11秒前
11秒前
标致小翠完成签到,获得积分10
12秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Femoral insertion of the ACL. Radiographic quadrant method 1000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3194343
求助须知:如何正确求助?哪些是违规求助? 2843259
关于积分的说明 8043993
捐赠科研通 2507735
什么是DOI,文献DOI怎么找? 1340010
科研通“疑难数据库(出版商)”最低求助积分说明 638854
邀请新用户注册赠送积分活动 607742