已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Urine Albumin Measurements in Clinical Diagnostics

尿 蛋白尿 白蛋白 肾脏疾病 指南 医学 内科学 病理
作者
Jesse C. Seegmiller,Lorin M Bachmann
出处
期刊:Clinical Chemistry [Oxford University Press]
卷期号:70 (2): 382-391 被引量:3
标识
DOI:10.1093/clinchem/hvad174
摘要

Abstract Background Measurement of urine albumin is critical for diagnosis, risk classification, and monitoring of chronic kidney disease (CKD). Guidelines recommend clinical decision cutoffs for the urine albumin-to-creatinine ratio (ACR) of 30 and 300 mg/g (3 and 30 mg/mmol). However, differences among manufacturers’ routine urine albumin measurement procedures have been found to exceed 40%, suggesting CKD diagnosis and risk classification may vary depending upon the specific measurement procedure implemented in the laboratory. Content This review discusses urine albumin pathophysiology and clinical practice guideline recommendations for CKD. The review also provides recommendations for urine specimen collection and storage, and results reporting for the ACR. Recent advances in measurement techniques and development of reference systems intended to facilitate standardization of urine albumin measurements are reviewed. Summary Urine albumin is an important measurement procedure used for diagnosis, risk classification, and management of CKD. Urine albumin results should be reported as the ACR using quantitative measurement procedures. Random urine collections used for albuminuria screening should be followed by confirmation with first morning void collections to reduce variation and increase diagnostic accuracy for urine albumin measurement. Most measurement procedures utilize immunoturbidimetric or immunonephelometric techniques. However, results vary significantly among measurement procedures, potentially resulting in differences in classification or risk assessment for CKD. The National Institute for Standards and Technology (NIST) and other laboratories are developing reference systems, including liquid chromatography–tandem mass spectrometry candidate reference measurement procedures and reference materials, to enable standardization of routine measurement procedures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
闪闪善若完成签到 ,获得积分10
1秒前
莫愁发布了新的文献求助30
3秒前
4秒前
8秒前
好巧完成签到,获得积分10
8秒前
9秒前
123zyuyu完成签到,获得积分10
10秒前
草莓啵啵兔完成签到 ,获得积分10
10秒前
wyy应助疯狂的思山采纳,获得10
12秒前
13秒前
如果完成签到 ,获得积分10
14秒前
14秒前
16秒前
koitoyu发布了新的文献求助10
17秒前
希望天下0贩的0应助levicho采纳,获得10
19秒前
nkcyn完成签到 ,获得积分10
19秒前
小花生完成签到,获得积分10
20秒前
魏魏发布了新的文献求助10
20秒前
lhw发布了新的文献求助10
20秒前
淡定的太清完成签到,获得积分20
21秒前
21秒前
21秒前
深情安青应助明理的从霜采纳,获得10
22秒前
23秒前
何hehe完成签到 ,获得积分10
23秒前
25秒前
充电宝应助Sekiro采纳,获得10
27秒前
levicho发布了新的文献求助10
29秒前
30秒前
32秒前
32秒前
Ben完成签到,获得积分20
33秒前
Fancy发布了新的文献求助10
35秒前
科研通AI2S应助魏魏采纳,获得10
35秒前
35秒前
549sysfzr发布了新的文献求助10
37秒前
我我我我完成签到,获得积分10
39秒前
40秒前
深秋远塞完成签到 ,获得积分10
41秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189653
求助须知:如何正确求助?哪些是违规求助? 2839039
关于积分的说明 8022491
捐赠科研通 2501879
什么是DOI,文献DOI怎么找? 1336060
科研通“疑难数据库(出版商)”最低求助积分说明 637750
邀请新用户注册赠送积分活动 605835