Urine Albumin Measurements in Clinical Diagnostics

尿 蛋白尿 白蛋白 肾脏疾病 指南 医学 内科学 病理
作者
Jesse C. Seegmiller,Lorin M Bachmann
出处
期刊:Clinical Chemistry [Oxford University Press]
卷期号:70 (2): 382-391 被引量:3
标识
DOI:10.1093/clinchem/hvad174
摘要

Abstract Background Measurement of urine albumin is critical for diagnosis, risk classification, and monitoring of chronic kidney disease (CKD). Guidelines recommend clinical decision cutoffs for the urine albumin-to-creatinine ratio (ACR) of 30 and 300 mg/g (3 and 30 mg/mmol). However, differences among manufacturers’ routine urine albumin measurement procedures have been found to exceed 40%, suggesting CKD diagnosis and risk classification may vary depending upon the specific measurement procedure implemented in the laboratory. Content This review discusses urine albumin pathophysiology and clinical practice guideline recommendations for CKD. The review also provides recommendations for urine specimen collection and storage, and results reporting for the ACR. Recent advances in measurement techniques and development of reference systems intended to facilitate standardization of urine albumin measurements are reviewed. Summary Urine albumin is an important measurement procedure used for diagnosis, risk classification, and management of CKD. Urine albumin results should be reported as the ACR using quantitative measurement procedures. Random urine collections used for albuminuria screening should be followed by confirmation with first morning void collections to reduce variation and increase diagnostic accuracy for urine albumin measurement. Most measurement procedures utilize immunoturbidimetric or immunonephelometric techniques. However, results vary significantly among measurement procedures, potentially resulting in differences in classification or risk assessment for CKD. The National Institute for Standards and Technology (NIST) and other laboratories are developing reference systems, including liquid chromatography–tandem mass spectrometry candidate reference measurement procedures and reference materials, to enable standardization of routine measurement procedures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
tao完成签到 ,获得积分10
1秒前
1秒前
winwinhhh发布了新的文献求助10
2秒前
科研通AI2S应助飘逸蜡烛采纳,获得10
2秒前
3秒前
pluto应助Beal Julien采纳,获得10
3秒前
5秒前
彭于晏应助西瓜藤子采纳,获得10
5秒前
8秒前
NexusExplorer应助Liu采纳,获得10
8秒前
宁祚完成签到,获得积分10
8秒前
在水一方应助科研通管家采纳,获得10
9秒前
科研通AI2S应助科研通管家采纳,获得10
9秒前
pluto应助科研通管家采纳,获得10
9秒前
CipherSage应助科研通管家采纳,获得30
9秒前
无花果应助科研通管家采纳,获得10
9秒前
李健应助科研通管家采纳,获得10
9秒前
8R60d8应助科研通管家采纳,获得100
9秒前
9秒前
世间安得双全法完成签到,获得积分0
10秒前
科研通AI2S应助科研通管家采纳,获得10
10秒前
CodeCraft应助科研通管家采纳,获得10
10秒前
天天快乐应助科研通管家采纳,获得30
10秒前
10秒前
科研通AI2S应助科研通管家采纳,获得10
10秒前
10秒前
10秒前
科研通AI2S应助科研通管家采纳,获得10
10秒前
小马甲应助科研通管家采纳,获得10
10秒前
10秒前
10秒前
fanmo完成签到 ,获得积分10
11秒前
12秒前
kylin完成签到,获得积分10
12秒前
liuttinn发布了新的文献求助10
12秒前
koyin发布了新的文献求助10
15秒前
完美世界应助肉肉采纳,获得10
18秒前
helong完成签到,获得积分10
20秒前
李明发布了新的文献求助10
20秒前
22秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
Актуализированная стратиграфическая схема триасовых отложений Прикаспийского региона. Объяснительная записка 360
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3191691
求助须知:如何正确求助?哪些是违规求助? 2841043
关于积分的说明 8031057
捐赠科研通 2504517
什么是DOI,文献DOI怎么找? 1337701
科研通“疑难数据库(出版商)”最低求助积分说明 638205
邀请新用户注册赠送积分活动 606684