Urine Albumin Measurements in Clinical Diagnostics

尿 蛋白尿 白蛋白 肾脏疾病 指南 医学 内科学 病理
作者
Jesse C. Seegmiller,Lorin M Bachmann
出处
期刊:Clinical Chemistry [Oxford University Press]
卷期号:70 (2): 382-391 被引量:3
标识
DOI:10.1093/clinchem/hvad174
摘要

Abstract Background Measurement of urine albumin is critical for diagnosis, risk classification, and monitoring of chronic kidney disease (CKD). Guidelines recommend clinical decision cutoffs for the urine albumin-to-creatinine ratio (ACR) of 30 and 300 mg/g (3 and 30 mg/mmol). However, differences among manufacturers’ routine urine albumin measurement procedures have been found to exceed 40%, suggesting CKD diagnosis and risk classification may vary depending upon the specific measurement procedure implemented in the laboratory. Content This review discusses urine albumin pathophysiology and clinical practice guideline recommendations for CKD. The review also provides recommendations for urine specimen collection and storage, and results reporting for the ACR. Recent advances in measurement techniques and development of reference systems intended to facilitate standardization of urine albumin measurements are reviewed. Summary Urine albumin is an important measurement procedure used for diagnosis, risk classification, and management of CKD. Urine albumin results should be reported as the ACR using quantitative measurement procedures. Random urine collections used for albuminuria screening should be followed by confirmation with first morning void collections to reduce variation and increase diagnostic accuracy for urine albumin measurement. Most measurement procedures utilize immunoturbidimetric or immunonephelometric techniques. However, results vary significantly among measurement procedures, potentially resulting in differences in classification or risk assessment for CKD. The National Institute for Standards and Technology (NIST) and other laboratories are developing reference systems, including liquid chromatography–tandem mass spectrometry candidate reference measurement procedures and reference materials, to enable standardization of routine measurement procedures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
zxy完成签到 ,获得积分10
1秒前
1秒前
李静完成签到,获得积分10
1秒前
1秒前
2秒前
重生之我怎么变院士了完成签到 ,获得积分10
2秒前
Jj7完成签到,获得积分10
3秒前
3秒前
哈哈完成签到,获得积分10
3秒前
curtisness应助走啊采纳,获得10
3秒前
活爹完成签到,获得积分10
4秒前
FashionBoy应助水水采纳,获得10
4秒前
xindiya发布了新的文献求助10
5秒前
5秒前
ding应助李静采纳,获得10
5秒前
HC完成签到,获得积分10
6秒前
今后应助奋斗觅海采纳,获得10
6秒前
陈陈陈完成签到,获得积分10
6秒前
芙蓉发布了新的文献求助30
6秒前
6秒前
账户已注销应助maodoudou采纳,获得30
7秒前
7秒前
7秒前
8秒前
8秒前
9秒前
完美世界应助小王不退学采纳,获得10
9秒前
晓晓发布了新的文献求助10
9秒前
传奇3应助专注灵凡采纳,获得30
9秒前
9秒前
迷路的小蕾完成签到,获得积分10
9秒前
9秒前
wq完成签到,获得积分10
10秒前
谁猪沉浮完成签到,获得积分10
10秒前
小马甲应助Astro采纳,获得10
10秒前
Veee完成签到,获得积分10
11秒前
12秒前
13秒前
霸气的夏蓉完成签到,获得积分20
13秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3184820
求助须知:如何正确求助?哪些是违规求助? 2835119
关于积分的说明 8003496
捐赠科研通 2497569
什么是DOI,文献DOI怎么找? 1332906
科研通“疑难数据库(出版商)”最低求助积分说明 636748
邀请新用户注册赠送积分活动 604139