Urine Albumin Measurements in Clinical Diagnostics

尿 蛋白尿 白蛋白 肾脏疾病 指南 医学 内科学 病理
作者
Jesse C. Seegmiller,Lorin M Bachmann
出处
期刊:Clinical Chemistry [Oxford University Press]
卷期号:70 (2): 382-391 被引量:3
标识
DOI:10.1093/clinchem/hvad174
摘要

Abstract Background Measurement of urine albumin is critical for diagnosis, risk classification, and monitoring of chronic kidney disease (CKD). Guidelines recommend clinical decision cutoffs for the urine albumin-to-creatinine ratio (ACR) of 30 and 300 mg/g (3 and 30 mg/mmol). However, differences among manufacturers’ routine urine albumin measurement procedures have been found to exceed 40%, suggesting CKD diagnosis and risk classification may vary depending upon the specific measurement procedure implemented in the laboratory. Content This review discusses urine albumin pathophysiology and clinical practice guideline recommendations for CKD. The review also provides recommendations for urine specimen collection and storage, and results reporting for the ACR. Recent advances in measurement techniques and development of reference systems intended to facilitate standardization of urine albumin measurements are reviewed. Summary Urine albumin is an important measurement procedure used for diagnosis, risk classification, and management of CKD. Urine albumin results should be reported as the ACR using quantitative measurement procedures. Random urine collections used for albuminuria screening should be followed by confirmation with first morning void collections to reduce variation and increase diagnostic accuracy for urine albumin measurement. Most measurement procedures utilize immunoturbidimetric or immunonephelometric techniques. However, results vary significantly among measurement procedures, potentially resulting in differences in classification or risk assessment for CKD. The National Institute for Standards and Technology (NIST) and other laboratories are developing reference systems, including liquid chromatography–tandem mass spectrometry candidate reference measurement procedures and reference materials, to enable standardization of routine measurement procedures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
科研通AI2S应助皮皮采纳,获得10
2秒前
如影随形发布了新的文献求助10
2秒前
3秒前
米米米发布了新的文献求助10
3秒前
4秒前
4秒前
5秒前
情怀应助米米米采纳,获得10
6秒前
明天发布了新的文献求助10
8秒前
Owen应助如影随形采纳,获得10
9秒前
乐乐发布了新的文献求助10
9秒前
KKLJOJ完成签到,获得积分10
9秒前
11秒前
Jasper应助典雅的俊驰采纳,获得10
13秒前
kjing完成签到,获得积分10
15秒前
feitian201861发布了新的文献求助10
16秒前
17秒前
18秒前
19秒前
xiongyh10完成签到,获得积分10
20秒前
uwu完成签到 ,获得积分10
21秒前
aaefv完成签到,获得积分10
22秒前
22秒前
忆往昔完成签到,获得积分10
22秒前
22秒前
22秒前
yc发布了新的文献求助10
24秒前
传奇3应助enen采纳,获得200
25秒前
Darkangel完成签到,获得积分10
25秒前
小辛发布了新的文献求助10
26秒前
平常的灵凡完成签到,获得积分10
27秒前
田様应助李串串采纳,获得10
27秒前
Albertxkcj发布了新的文献求助10
27秒前
李健的小迷弟应助swbbb采纳,获得10
27秒前
28秒前
完美世界应助CHR采纳,获得10
28秒前
英俊的铭应助CHR采纳,获得10
28秒前
29秒前
Leo发布了新的文献求助10
31秒前
32秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3195077
求助须知:如何正确求助?哪些是违规求助? 2843978
关于积分的说明 8047611
捐赠科研通 2508403
什么是DOI,文献DOI怎么找? 1340814
科研通“疑难数据库(出版商)”最低求助积分说明 639022
邀请新用户注册赠送积分活动 607994