抗氧化剂
传统医学
化学
IC50型
功能性食品
药用植物
食品科学
生物化学
体外
医学
作者
Qu-Jing Luo,Wenchao Zhou,Xin-Yi Liu,Yajie Li,Qingling Xie,Bin Wang,Chao Liu,Wen-Mao Wang,Wei Wang,Xu-Dong Zhou
出处
期刊:Molecules
[MDPI AG]
日期:2023-12-05
卷期号:28 (24): 7956-7956
被引量:2
标识
DOI:10.3390/molecules28247956
摘要
Ampelopsis grossedentata is a valuable medicinal and edible plant, which is often used as a traditional tea by the Tujia people in China. A. grossedentata has numerous biological activities and is now widely used in the pharmaceutical and food industries. In this study, two new flavonoids (1-2) and seventeen known compounds (3-19) were isolated and identified from the dried stems and leaves of A. grossedentata. These isolated compounds were characterized by various spectroscopic data including mass spectrometry and nuclear magnetic resonance spectroscopy. All isolates were assessed for their α-glucosidase inhibitory, antioxidant, and hepatoprotective activities, and their structure-activity relationships were further discussed. The results indicated that compound 1 exhibited effective inhibitory activity against α-glucosidase, with an IC50 value of 0.21 μM. In addition, compounds 1-2 demonstrated not only potent antioxidant activities but also superior hepatoprotective properties. The findings of this study could serve as a reference for the development of A. grossedentata-derived products or drugs aimed at realizing their antidiabetic, antioxidant, and hepatoprotective functions.
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