Introduction of Difluoromethyl through Radical Pathways

Abstract During the past decade, radical difluoromethylation has emerged as a powerful and versatile tool for the incorporation of difluoromethyl into various organic compounds. These reactions feature mild reaction conditions, very good functional group compatibilities, and quite broad substrate scopes, thus having drawn much attention and got rapid developments. A diverse range of difluoromethyl radical precursors have been developed for a series of radical difluoromethylation reactions. This review summarizes and discusses the advance in the radical difluoromethylation reactions, which are organized according to the protocols of generating difluoromethyl radical.