细胞生物学
条件基因敲除
结肠炎
细胞因子
粘蛋白
炎症
基因剔除小鼠
免疫学
化学
生物
受体
生物化学
表型
基因
作者
Ankita Singh,Michael Beaupre,Cecilia Villegas-Novoa,Kiyoshi Shiomitsu,Stephen Gaudino,Suzanne Tawch,Ruhee Damle,Cody Kempen,Biswa Choudhury,Jeremy P. McAleer,Brian S. Sheridan,Paula Denoya,Richard S. Blumberg,Patrick Hearing,Nancy L. Allbritton,Pawan Kumar
出处
期刊:Cell Reports
[Elsevier]
日期:2024-05-01
卷期号:43 (5): 114206-114206
被引量:2
标识
DOI:10.1016/j.celrep.2024.114206
摘要
The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of intestinal epithelial cell (IEC). By using a range of IEC type-specific Il22Ra1 conditional knockout mice and a dextran sulfate sodium (DSS) colitis model, we demonstrate that IL-22Ra1 signaling in MATH1
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