阿霉素
三阴性乳腺癌
癌症
外体
微泡
乳腺癌
癌症研究
癌症干细胞
干细胞
化学
癌细胞
纳米颗粒
纳米技术
医学
材料科学
内科学
细胞生物学
生物
化疗
生物化学
小RNA
基因
作者
Rupali Sarkar,Souradeep Biswas,Rituparna Ghosh,Priya Samanta,Shampa Pakhira,Mrinmoyee Mondal,Yashwant Gupta,Suman Bhandary,Prosenjit Saha,Arijit Bhowmik,Subhadip Hajra
标识
DOI:10.1186/s12951-024-02518-0
摘要
Therapeutic management of locally advanced and metastatic triple negative breast cancer (TNBC) is often limited due to resistance to conventional chemotherapy. Metastasis is responsible for more than 90% of breast cancer-associated mortality; therefore, the clinical need to prevent or target metastasis is immense. The epithelial to mesenchymal transition (EMT) of cancer stem cells (CSCs) is a crucial determinant in metastasis. Doxorubicin (DOX) is the frequently used chemotherapeutic drug against TNBC that may increase the risk of metastasis in patients. After cancer treatment, CSCs with the EMT characteristic persist, which contributes to advanced malignancy and cancer recurrence. The latest developments in nanotechnology for medicinal applications have raised the possibility of using nanomedicines to target these CSCs. Hence, we present a novel approach of combinatorial treatment of DOX with dietary indole 3,3'-diindolylmethane (DIM) which is an intriguing field of research that may target CSC mediated EMT induction in TNBC. For efficient delivery of both the compounds to the tumor niche, advance method of drug delivery based on exosomes sheathed with mesoporous silica nanoparticles may provide an attractive strategy.
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