免疫原性
瓦博格效应
癌症研究
癌细胞
癌症
医学
免疫系统
内科学
免疫学
作者
José Antonio Enrı́quez,Marı́a Mittelbrunn
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-04-24
卷期号:84 (13): 2043-2045
标识
DOI:10.1158/0008-5472.can-24-1304
摘要
Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition, the metabolic shift modulates the immunogenicity of the tumor cells. Recently, Mahmood and colleagues reported a connection between mitochondrial DNA mutations in cancer cells and their response to immunotherapy in a mouse model of melanoma.
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