体内分布
化学
正电子发射断层摄影术
体内
分子成像
Pet成像
显像剂
Spect成像
体外
癌症研究
核医学
医学
生物化学
生物
生物技术
作者
Jiawen Huang,Lu Bai,Dehao Shi,Wenhao Jiang,Pan Chen,Dong Ye,Xiaojun Zhang,Jiangling Peng,Jinqiang Hou,Yu‐Jing Lu,Huang Xiao-hong,Ganghua Tang,Shun Huang
标识
DOI:10.1021/acs.molpharmaceut.3c01228
摘要
GRP78, a member of the HSP70 superfamily, is an endoplasmic reticulum chaperone protein overexpressed in various cancers, making it a promising target for cancer imaging and therapy. Positron emission tomography (PET) imaging offers unique advantages in real time, noninvasive tumor imaging, rendering it a suitable tool for targeting GRP78 in tumor imaging to guide targeted therapy. Several studies have reported successful tumor imaging using PET probes targeting GRP78. However, existing PET probes face challenges such as low tumor uptake, inadequate in vivo distribution, and high abdominal background signal. Therefore, this study introduces a novel peptide PET probe, [
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