黑色素瘤
危险分层
医学
免疫系统
全身疗法
转移
模式
生物信息学
免疫学
癌症研究
生物
内科学
癌症
乳腺癌
社会科学
社会学
作者
Mali Barbi,Richard D. Carvajal,Craig Devoe
出处
期刊:The cancer journal
[Ovid Technologies (Wolters Kluwer)]
日期:2024-03-01
卷期号:30 (2): 92-101
被引量:3
标识
DOI:10.1097/ppo.0000000000000708
摘要
Abstract Uveal melanoma (UM), arising from intraocular melanocytes, poses a complex clinical challenge with a substantial risk of distant metastasis, often to the liver. Molecular profiling, encompassing genetic, cytogenetic, gene expression, and immunological subsets, plays a pivotal role in determining prognoses. The evolving landscape includes promising systemic treatments, such as tebentafusp, a novel immune-modulating bispecific fusion protein, and targeted therapies. Combined regional and systemic approaches, including immune checkpoint inhibitors and innovative liver-directed therapy, are also under investigation. Although recent progress has improved outcomes, ongoing research aims to address the unique challenges of UM and develop effective therapies, particularly for HLA-A*02:01–negative patients who represent a significant unmet medical need. This review comprehensively discusses the molecular characteristics of UM, risk stratification methods, and the current and future spectrum of regional and systemic therapeutic modalities.
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