Exploiting the mechanical effects of ultrasound for noninvasive therapy
超声波
医学
放射科
作者
Meaghan A. O’Reilly
出处
期刊:Science [American Association for the Advancement of Science (AAAS)] 日期:2024-09-12卷期号:385 (6714)
标识
DOI:10.1126/science.adp7206
摘要
Focused ultrasound is a platform technology capable of eliciting a wide range of biological responses with high spatial precision deep within the body. Although focused ultrasound is already in clinical use for focal thermal ablation of tissue, there has been a recent growth in development and translation of ultrasound-mediated nonthermal therapies. These approaches exploit the physical forces of ultrasound to produce a range of biological responses dependent on exposure conditions. This review discusses recent advances in four application areas that have seen particular growth and have immense clinical potential: brain drug delivery, neuromodulation, focal tissue destruction, and endogenous immune system activation. Owing to the maturation of transcranial ultrasound technology, the brain is a major target organ; however, clinical indications outside the brain are also discussed.