微泡
医学
糖尿病足
再生(生物学)
糖尿病足溃疡
伤口愈合
小RNA
炎症
外体
生物信息学
发病机制
糖尿病
病态的
癌症研究
免疫学
内科学
细胞生物学
生物
内分泌学
生物化学
基因
作者
Lifei Guo,Dan Xiao,Helin Xing,Guodong Yang,Xuekang Yang
出处
期刊:Burns & Trauma
[Oxford University Press]
日期:2024-01-01
卷期号:12
被引量:3
标识
DOI:10.1093/burnst/tkae023
摘要
Abstract Diabetic foot ulcer (DFU), characterized by high recurrence rate, amputations and mortality, poses a significant challenge in diabetes management. The complex pathology involves dysregulated glucose homeostasis leading to systemic and local microenvironmental complications, including peripheral neuropathy, micro- and macro-angiopathy, recurrent infection, persistent inflammation and dysregulated re-epithelialization. Novel approaches to accelerate DFU healing are actively pursued, with a focus on utilizing exosomes. Exosomes are natural nanovesicles mediating cellular communication and containing diverse functional molecular cargos, including DNA, mRNA, microRNA (miRNA), lncRNA, proteins, lipids and metabolites. While some exosomes show promise in modulating cellular function and promoting ulcer healing, their efficacy is limited by low yield, impurities, low loading content and inadequate targeting. Engineering exosomes to enhance their curative activity represents a potentially more efficient approach for DFUs. This could facilitate focused repair and regeneration of nerves, blood vessels and soft tissue after ulcer development. This review provides an overview of DFU pathogenesis, strategies for exosome engineering and the targeted therapeutic application of engineered exosomes in addressing critical pathological changes associated with DFUs.
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