纳米囊
纳米载体
紫杉醇
药物输送
体内
生物利用度
药品
肺表面活性物质
化学
纳米技术
药理学
材料科学
医学
化疗
纳米颗粒
有机化学
外科
生物化学
生物
生物技术
作者
Yanping Deng,Zhenhong Du,Shunfu Du,Nan Li,Wenjing Wang,Kongzhao Su,Daqiang Yuan
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-10-12
卷期号:7 (11): 7535-7543
标识
DOI:10.1021/acsabm.4c01123
摘要
The search for drug nanocarriers with stimuli-responsive properties and high payloads for targeted drug delivery and precision medicine is currently a focal point of biomedical research, but this endeavor still encounters various challenges. Herein, a porous organic cage (POC) is applied to paclitaxel (PTX) drug delivery for cancer therapy for the first time. Specifically, water-soluble, stable, and biocompatible POC-based nanocapsules (PTX@POC@RH40) with PTX encapsulation efficiency over 98% can be synthesized by simply grafting nonionic surfactant (Polyoxyl 40 hydrogenated castor oil, RH40) on the POC surface. These PTX@POC@RH40 nanocapsules demonstrate remarkable stability for more than a week without aggregation and exhibit pH-responsive behavior under acidic conditions (pH 5.5) and display sustained release behavior at both pH 7.4 and pH 5.5. Intravenous administration of PTX@POC@RH40 led to a 3.5-fold increase in PTX bioavailability compared with the free PTX group in rats. Moreover, in vivo mouse model experiments involving 4T1 subcutaneous breast cancer tumors revealed that PTX@POC@RH40 exhibited enhanced anticancer efficacy with minimal toxicity compared with free PTX. These findings underscore the potential of POCs as promising nanocarriers for stimuli-responsive drug delivery in therapeutic applications.
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