肠道菌群
生物
代谢综合征
槲皮素
白色脂肪组织
褐色脂肪组织
串扰
脂肪组织
产热
肥胖
胆汁酸
内分泌学
腹部肥胖
内科学
生物化学
医学
抗氧化剂
物理
光学
作者
Xiaoqiang Zhu,Xiaojuan Dai,Lijun Zhao,Jing Li,Yanhong Zhu,Wenjuan He,Xin‐Lei Guan,Tao Wu,Li Liu,Hongping Song,Lei Liang
标识
DOI:10.1080/19490976.2024.2390136
摘要
Abdominal obesity-related metabolic syndrome (MetS) has emerged as a significant global public health issue that affects human health. Flavonoids, such as quercetin, have been reported to exert obvious anti-obesity and lipid-lowering effects in both humans and animal models. However, the precise underlying mechanism remains elusive. In this study, we investigated the potential roles of gut microbiota-bile acids (BAs) interactions in quercetin-induced anti-obesity effects and metabolic benefits. Oral administration of quercetin significantly enhanced energy metabolism through activating thermogenesis of brown adipose tissues (BAT) and browning of white adipose tissues (WAT), thus mitigating metabolic dysfunctions in an abdominal obesity-related MetS mouse model. Further mechanistic studies demonstrated that quercetin treatment substantially promoted the generation of non-12α-hydroxylated BAs (non-12OH BAs), particularly ursodeoxycholic acid (UDCA) and lithocholic acid (LCA), in serum via regulating the overall structure of gut microbiota and enriching
科研通智能强力驱动
Strongly Powered by AbleSci AI