部分
立体化学
红树林
真菌
细胞毒性
生物
同族
绝对构型
拉伤
细胞毒性T细胞
发酵
细胞培养
化学
生物化学
植物
体外
有机化学
遗传学
生态学
解剖
作者
Siwen Niu,Jianlin He,Shuhuan Huang,Shouyuan Wu,Ling Zeng,Juan Wang,Bihong Hong,Ziming Chen
出处
期刊:Marine Drugs
[MDPI AG]
日期:2022-09-21
卷期号:20 (10): 591-591
被引量:3
摘要
Chemical examination of the fermented broth of the mangrove-derived fungus Phaeosphaeriopsis sp. S296 resulted in the isolation of two new cyclodecadepsipeptides, namely phaeosphamides A (1) and B (2), as well as one known congener Sch 217048 (3). The structures of new metabolites, including absolute configurations, were established on the basis of extensive spectroscopic data analyses, chemical conversion, and Marfey’s method. The 2-hydroxy-3-methylpentanoic acid (Hmp) moiety and pipecolic acid (Pip) unit in structures were rarely discovered in nature. Interestingly, compounds 1–3 are examples of peptides discovered from the fungal genus Phaeosphaeriopsis for the first time. All identified compounds were evaluated for their cytotoxicity against five tumor cell lines of AGS, BEL-7402, HepG2, B16, and BIU87. Among them, compound 1 showed inhibitory activities against these tumor cell lines with IC50 values ranging from 5.14 to 66.38 μM. A further mechanistic investigation found that 1 arrested AGS cells in the G2 phase and induced their apoptosis in a dose-dependent manner.
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