Recent Advancements in Biomimetic Drug Delivery System of Single- Chain Fatty Acids as Ufasomes and Ufosomes: A Comprehensive Review

药品 药物输送 靶向给药 生物利用度 药理学 纳米技术 医学 材料科学
作者
Lakhvir Kaur,Manjeet Kaur,Gurjeet Singh,Lovepreet Singh,Amarjeet Kaur,Ravi Kumar Dhawan
出处
期刊:Current Nanoscience [Bentham Science]
卷期号:19 (3): 362-371 被引量:2
标识
DOI:10.2174/1573413718666220919113148
摘要

Abstract: The current review is focused on many carrier systems and technologies that have recently been explored for achieving controlled drug release, promoting therapeutic potential, and selectivity. Among various carrier systems, the vesicular drug delivery system is the highly effective method of delivering medication to the infection site resulting in minimal drug toxicity and adverse effects. Various research studies have been conducted to reduce drug loss and degradation, prevent unwanted side effects, improve drug bioavailability, and retain the fraction of drug in the necessary region. To achieve these goals novel vesicular drug delivery and vesicular drug targeting systems, such as ufasomes and ufosomes, are currently under research. They are highly ordered self-assembled novel vesicular drug delivery systems formed from disordered building blocks into highly ordered systems by specific inter-block mutual interactions. These two carrier systems are separately being studied for their efficacy to improve the effectiveness of various drugs. In this perspective, we summarized the basic concept and recent studies on ufasomes and ufosomes for drug delivery along with pertinent investigations in the present review. The vesicular systems discussed in this article are given chronologically, from existing systems to advanced fatty acid vesicles. Drug design and development using ufasome and ufosome vesicular systems have added a new dimension to the treatment of disease conditions by circumventing penetration limiting obstacles and therefore increasing efficacy.
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