血小板
急性白血病
平均血小板体积
医学
血小板输注
造血
白血病
恶性肿瘤
免疫学
内科学
干细胞
生物
细胞生物学
作者
Li Zhang,Jing Liu,Xiang Qin,Wenjun Liu
标识
DOI:10.1016/j.cca.2022.09.015
摘要
Acute leukemia (AL) is a hematological malignancy with high morbidity and mortality that is caused by abnormal hematopoietic stem cells. AL can change the parameters, quality, and function of platelets through numerous mechanisms, resulting in bleeding and even death in AL patients. Hence, AL patients are often clinically treated using normal platelet transfusion. However, studies have found that platelets can also affect AL cells. This review discusses the changes occurring in platelet count, mean platelet volume, platelet distribution width, reticulated platelets, platelet membrane glycoprotein, platelet aggregation, and activation in AL patients, the causes of these changes, and the possible significance of these changes for patient prognosis. The effects of platelets on the proliferation and drug resistance of AL cells are also discussed.
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