Preclinical evidence for quercetin against inflammatory bowel disease: a meta-analysis and systematic review

医学 槲皮素 炎症性肠病 丙二醛 髓过氧化物酶 超氧化物歧化酶 荟萃分析 呼出气一氧化氮 疾病 药理学 氧化应激 免疫学 内科学 胃肠病学 抗氧化剂 炎症 全身炎症 生物 生物化学
作者
Shuangyuan Hu,Maoyuan Zhao,Wei Li,Pengfei Wei,Бо Лю,Shuanglan chen,Jinhao Zeng,Xiao Ma,Jian-Yuan Tang
出处
期刊:Inflammopharmacology [Springer Nature]
卷期号:30 (6): 2035-2050 被引量:18
标识
DOI:10.1007/s10787-022-01079-8
摘要

Inflammatory bowel disease (IBD) is a chronic, potentially cancerous disease with limited treatment options. Quercetin may be a novel treatment for IBD. However, its efficacy and safety are unknown. Our goal was to conduct a systematic evaluation to summarize the preclinical effects of quercetin, which may help guide future studies.The literature was drawn from three English databases (PubMed, Embase, and Web of Science), and the quality of the included literature was assessed using the SYRCLE list (10 items). The meta-analysis was performed using STATA 15.1 software.A total of 11 animal studies with 199 animals were involved. The current meta-analysis showed that quercetin could reduce histological score (HS), Disease Activity Index (DAI), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), nitric oxide(NO), malondialdehyde (MDA), myeloperoxidase (MPO) activity and increase colon length (CL), weight change degree (WCD), interleukin-10 (IL-10), glutathione (GSH), superoxide dismutase (SOD) activity and catalase (CAT) activity, which may involve anti-inflammatory, anti-oxidative stress, cytoprotective, barrier protection, flora regulation.In conclusion, preclinical evidence suggests that quercetin is an ideal agent for IBD treatment. However, the validity of the findings may be compromised by the low methodological quality and the small number of studies included. There may be some discrepancies between the results of the current analysis and the real situation. More rigorous experimental designs and more comprehensive studies are needed to test the protection of quercetin against IBD.
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