肿瘤微环境
癌症免疫疗法
材料科学
免疫疗法
癌症
免疫系统
免疫原性细胞死亡
癌症研究
程序性细胞死亡
线粒体
光动力疗法
癌细胞
免疫检查点
细胞生物学
细胞凋亡
免疫学
化学
生物
生物化学
有机化学
遗传学
作者
Cong Huang,Bingquan Lin,Chuyao Chen,Huaiming Wang,Xiaosheng Lin,Бо Лю,Qingfan Ren,Jia Tao,Peng Zhao,Yikai Xu
标识
DOI:10.1002/adma.202207593
摘要
Abstract Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes a two‐way enhancement of ICD based on a CaO 2 @CuS–MnO 2 @HA (CCMH) nanocomposite to overcome the insufficient damage‐associated molecular patterns (DAMPs) of conventional ICD‐inducers. The near‐infrared (NIR) irradiation (1064 nm) of CuS nanoparticles generates 1 O 2 through photodynamic therapy (PDT) to trigger ICD, and it also damages the Ca 2+ buffer function of mitochondria. Additionally, CaO 2 nanoparticles react with H 2 O to produce a large amount of O 2 and Ca 2+ , which respectively lead to enhanced PDT and Ca 2+ overload during mitochondrial damage, thereby triggering a robust ICD activation. Moreover, oxidative‐damaged mitochondrial DNA, induced by PDT and released from tumor cells, reprograms the immunosuppressive tumor microenvironment by transforming tumor‐associated macrophages to the M1 subphenotype. This study shows that CCMH with NIR‐II irradiation can elicit adequate DAMPs and an active tumor‐immune microenvironment for both 4T1 and CT26 tumor models. Combining this method with an immune checkpoint blockade can realize an improved immunotherapy efficacy and long‐term protection effect for body.
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