有机体
细胞外小泡
微泡
生物
药物输送
核酸
免疫系统
胞外囊泡
细胞生物学
小RNA
计算生物学
化学
生物化学
免疫学
遗传学
基因
有机化学
作者
Rahul Sanwlani,Pamali Fonseka,Sai V. Chitti,Suresh Mathivanan
出处
期刊:Proteomes
[MDPI AG]
日期:2020-05-13
卷期号:8 (2): 11-11
被引量:114
标识
DOI:10.3390/proteomes8020011
摘要
Milk is considered as more than a source of nutrition for infants and is a vector involved in the transfer of bioactive compounds and cells. Milk contains abundant quantities of extracellular vesicles (EVs) that may originate from multiple cellular sources. These nanosized vesicles have been well characterized and are known to carry a diverse cargo of proteins, nucleic acids, lipids and other biomolecules. Milk-derived EVs have been demonstrated to survive harsh and degrading conditions in gut, taken up by various cell types, cross biological barriers and reach peripheral tissues. The cargo carried by these dietary EVs has been suggested to have a role in cell growth, development, immune modulation and regulation. Hence, there is considerable interest in understanding the role of milk-derived EVs in mediating inter-organismal and cross-species communication. Furthermore, various attributes such as it being a natural source, as well as its abundance, scalability, economic viability and lack of unwarranted immunologic reactions, has generated significant interest in deploying milk-derived EVs for clinical applications such as drug delivery and disease therapy. In this review, the role of milk-derived EVs in inter-organismal, cross-species communication and in drug delivery is discussed.
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