色素沉着
皮肤病科
黑色素
化学
皮肤美白
透皮
药理学
药物输送
药品
活性成分
医学
材料科学
纳米技术
生物化学
作者
Yushuai Wang,Weihan Yang,Wei Gao,Lu Zhang,Fang Wei,Huan Liu,Shuya Wang,Yingying Li,Weiman Zhao,Tao Ma,Qingqing Wang
标识
DOI:10.1016/j.ejps.2021.105749
摘要
Hyperpigmentation is a common skin disorder caused by excessive melanogenesis and uneven dispersion of melanin in the skin. To combine multiple active agents with an efficient transdermal drug delivery system is an effective strategy to combat UV induced skin pigmentation. In this work, Arbutin (Arb) and Vitamin C (Vc) mixed in 1:1 were found to have the greatest inhibition effects on melanogenesis and tyrosinase activity in B16 murine melanoma cells. And hyaluronic acid (HA) based dissolving microneedles array (DMNA) was employed to overcome the skin barriers for improved topical drug delivery, which exhibited the most desirable features, including morphology, mechanical properties, dissolving ability, and the highest drug loading. Furthermore, DMNA could greatly increase the stability of Vc during storage without adding any antioxidant which is an important issue for Vc administration. Pharmacodynamics study showed that DMNA loaded with Arb and Vc could synergistically suppress UVB-induced hyperpigmentation in guinea pig skin. This work provides a promising treatment strategy and solution for skin pigmentation and other skin problems.
科研通智能强力驱动
Strongly Powered by AbleSci AI