医学
近距离放射治疗
背景(考古学)
宫颈癌
药方
医学物理学
放射治疗计划
癌症
肿瘤科
放射治疗
内科学
药理学
生物
古生物学
作者
Kari Tanderup,N. Nesvacil,Kathrin Kirchheiner,M Şerban,S. Spampinato,Nina Boje Kibsgaard Jensen,Maximilian Schmid,Sofie de Smet,Henrike Westerveld,Stefan Ecker,Umesh Mahantshetty,Jamema Swamidas,Supriya Chopra,Remi A. Nout,Li Tee Tan,Lars Fokdal,Alina Sturdza,Ina M. Jürgenliemk-Schulz,Astrid de Leeuw,Jacob Christian Lindegaard,Christian Kirisits,Richard Pötter
标识
DOI:10.1016/j.semradonc.2020.05.008
摘要
The last 2 decades have witnessed the development and broad adoption of image-guided adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally advanced cervical cancer. A variety of brachytherapy techniques and dose/fractionation schedules have been applied, and until recently, there was no strong evidence available for preferring one approach to another. However, large volumes of data have now provided high level clinical evidence for dose-effect relations for both disease and morbidity endpoints. It is therefore now possible to apply evidence based dose planning aims and dose prescription protocols in IGABT for locally advanced cervical cancer. This review gives an overview of targets/organs-at-risk and disease/morbidity endpoints which are relevant in the context of treatment planning and dose prescription in IGABT. The dosimetric and clinical evidence is summarized to support the implementation of dose prescription protocols which include hard and soft constraints for targets and organs at risk.
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