氰化
化学
双重角色
组合化学
催化作用
对偶(语法数字)
铜
功能群
简单
有机化学
艺术
文学类
哲学
聚合物
认识论
作者
Hao Zhang,Ziyan Wei,Ai Hua Zhang,Shouyun Yu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-08-31
卷期号:22 (18): 7315-7320
被引量:17
标识
DOI:10.1021/acs.orglett.0c02659
摘要
An efficient strategy for the synthesis of pharmaceutically important and synthetically useful cyanoimines, as well as cyanamides, has been described. This strategy is enabled by dual photoredox/copper-catalyzed cyanation of O-acyl oximes or O-acyl hydroxamides. This state of the art protocol for cyanoimines and cyanamides features readily available starting materials, mild reaction conditions, good functional group tolerance, and operational simplicity. The resultant cyanoimines can be transformed into structurally diverse and functionally important N-containing heterocycles.
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