The contribution of WTAP gene variants to Wilms tumor susceptibility

生物 威尔姆斯瘤 遗传学 基因 计算生物学
作者
Li Ma,Rui‐Xi Hua,Huiran Lin,Jinhong Zhu,Wen Fu,Lin Ao,Jiao Zhang,Jiwen Cheng,Haixia Zhou,Suhong Li,Zhuo Zhang,Jing He
出处
期刊:Gene [Elsevier BV]
卷期号:754: 144839-144839 被引量:9
标识
DOI:10.1016/j.gene.2020.144839
摘要

Wilms tumor is the most frequently occurring pediatric renal malignancy. Wilms tumor suppressor-1-associated protein (WTAP) is a vital component of N6-methyltransferase complex involved in tumorigenesis. However, the roles of WTAP gene single nucleotide polymorphisms (SNPs) in Wilms tumor risk have not been clarified to date. We successfully genotyped three WTAP gene SNPs using TaqMan assay in 405 Wilms tumor patients and 1197 cancer-free controls of Chinese children. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to determine the effects of WTAP gene SNPs on Wilms tumor risk. Carriers of the rs1853259 G variant are less susceptible to developing Wilms tumor, with an adjusted OR of 0.78 (AG vs. AA: 95% CI = 0.61-0.995, P = 0.046). Single locus analysis of rs9457712 G > A and rs7766006 G > T, as well as the combined analysis of risk genotypes, failed to unveil an association with Wilms tumor risk, respectively. Stratified analysis of the three SNPs and their combined risk effects showed more significant relationships with Wilms tumor risk under certain subgroups. In all, we found weak evidence of the association between WTAP gene SNPs and the risk of Wilms tumor. Further replication studies with greater sample size and different ethnicities are necessary to verify our findings.
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