Metformin kinetics in healthy subjects and in patients with diabetes mellitus.

British Journal of Clinical PharmacologyVolume 12, Issue 2 p. 235-246 Free Access Metformin kinetics in healthy subjects and in patients with diabetes mellitus. GT Tucker, GT TuckerSearch for more papers by this authorC Casey, C CaseySearch for more papers by this authorPJ Phillips, PJ PhillipsSearch for more papers by this authorH Connor, H ConnorSearch for more papers by this authorJD Ward, JD WardSearch for more papers by this authorHF Woods, HF WoodsSearch for more papers by this author GT Tucker, GT TuckerSearch for more papers by this authorC Casey, C CaseySearch for more papers by this authorPJ Phillips, PJ PhillipsSearch for more papers by this authorH Connor, H ConnorSearch for more papers by this authorJD Ward, JD WardSearch for more papers by this authorHF Woods, HF WoodsSearch for more papers by this author First published: August 1981 https://doi.org/10.1111/j.1365-2125.1981.tb01206.xCitations: 313AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat REFERENCES ASSAM, R., HEUCLIN, Ch., CANEVAL, D., BISMUTH, Ch., GEORGE, J. & GIRARD, J.R. (1977). Metformin-induced lactic acidosis in the presence of acute renal failure. Diabetologia, 13, 211– 217. BECKMANN, R. (1969). Resorption, Verteilung im organismus und Ausscheidung von Metformin. Diabetologia, 3, 318– 324. BERGMAN, U., BOMAN, G. & WIHOLM, B.-E. (1978). Epidemiology of adverse drug reactions to phenformin and metformin. Br. med. J., U 464– 466. BOXENBAUM, H.G., RIEGELMAN, S. & ELASHOFF, R.M. (1974). Statistical estimations in pharmacokinetics. J. Pharmacokin. Biopharm., 2, 123– 148. BRITISH MEDICAL JOURNAL (1977). Editorial. Biguanides and lactic acidosis in diabetics. Br. med. J., 2, 1436. GIBALDI, M. & PERREER, D. (1975). Pharmacokinetics. New York: Marcel Dekker. GOMENI, R. & GOMENI, C. (1978). IGPHARM: Interactive graphics package for pharmacokinetic analysis. Comput. Biomed. Res., 11 345– 361. GONDA, I. & HARPUR, E.S. (1980). Accumulation in the peripheral compartment of a linear two-compartment open model. J. Pharmacokin. Biopharm., 8, 99– 104. IRSIGLER, K., KRTTZ, H., REGAL, H. & KASPAR, L. (1979). Biguanid-indazierte und biguanid-assoziierte laktazidose. Serum- und gewebsspiegel der biguanide bei hyperlaktamie und laktazidose. Wien. Klin. Wchschr., 91, 59– 65. LENNARD, M.S., CASEY, C., TUCKER, G.T. & WOODS, H.F. (1978). Determination of metformin in biological samples. Br. J. clin. Pharmac., 6, 183– 185. LOO, J.C.K. & RIEGELMAN, S. (1968). A new method for calculating the intrinsic absorption rate of drugs. J. pharm. Sri., 57, 918– 928. NOEL, M. (1979). Kinetic study of normal and sustained release dosage forms of metformin in normal subjects. Res. clin. Forums, 1, 33– 44. PENTIKÄINEN, P.J., NEUVONEN, P.J. & PENTTILA, A. (1979). Pharmacokinetics of metformin after intravenous and oral administration to man. Eur. J. clin. Pharmac., 16, 195– 202. PHILLIPS, P.J., THOMAS, D.W. & HARDING, B.E. (1977). Biguanides and lactic acidosis. Br. med. J., 1, 234. SIRTORI, C.R., FRANCHESCHINI, G., GALLI-KIENLE, M., CIGHETTI, G. GALLI, G., BONDIOLI, A. & CONTI, F. (1978). Disposition of metformin (N, N- dimethylbiguanide) in man. Clin. Pharmac. Ther., 24, 683– 693. VAUGHAN, D.P. & DENNIS, M. (1978). Mathematical basis of point-area deconvolution method for determining in vivo input functions. J. pharm. Sci., 67, 663– 665. WAGNER, J.G. (1975). Fundamentals of Clinical Pharmacokinetics, 1st Edn, p l36. Hamilton, Illinois: Drug Intelligence Publications Inc. WEDER, H.C., SCHILDKNECHT, J. & KESSELRING, P. (1971). A new equilibrium dialyzing system. Amer. Lab., 10, 15– 21. Citing Literature Volume12, Issue2August 1981Pages 235-246 ReferencesRelatedInformation