烟碱激动剂
海马结构
乙酰胆碱
化学
乙酰胆碱受体
胆碱能的
神经节型烟碱受体
α-4β-2烟碱受体
烟碱乙酰胆碱受体
受体
兴奋剂
星形胶质细胞
内分泌学
生物
细胞生物学
内科学
生物化学
医学
中枢神经系统
作者
Yan Wang,Ning Zhu,Kewan Wang,Zhongyi Zhang,Yong Wang
出处
期刊:PubMed
日期:2012-08-05
卷期号:7 (22): 1709-14
被引量:12
标识
DOI:10.3969/j.issn.1673-5374.2012.22.005
摘要
The present study found expressions of α7 nicotinic acetylcholine receptor on hippocampal slices and hippocampal astrocytes using double immunofluorescence stainings. Expression of glial fibrillary acidic protein in the cultured hippocampal slices and hippocampal astrocytes significantly increased, and levels of macrophage inflammatory protein 1α, RANTES, interleukin-1β, interleukin-6, and tumor necrosis factor-α increased in the supernatant of cultured astrocytes following exposure to 200 nM amyloid β protein 1-42. Preconditioning of 10 μM nicotine, a nicotinic acetylcholine receptor agonist, could attenuate the influence of amyloid β protein 1-42 in inflammatory mediator secretion of cultured astrocytes. Experimental findings indicated that α7 nicotinic acetylcholine receptor was expressed on the surface of hippocampal astrocytes, and activated α7 nicotinic acetylcholine receptor was shown to inhibit inflammation induced by amyloid β protein 1-42.
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