化学
羟类固醇脱氢酶
联苯
脱氢酶
酶
立体化学
生物化学
药理学
有机化学
医学
作者
Rupinder K Lota,Sachin Dhanani,Caroline P Owen,Sabbir Ahmed
出处
期刊:Letters in Drug Design & Discovery
[Bentham Science]
日期:2007-04-01
卷期号:4 (3): 180-184
被引量:10
标识
DOI:10.2174/157018007780077417
摘要
We report the search for non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, for types 1 and 3. The results show that the synthesised compounds based on the biphenyl backbone were good inhibitors of 17β-HSD1, but were weak inhibitors of 17β-HSD3. The compounds were evaluated against 3β-HSD but showed weak inhibition. Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme inhibition, Biphenyl ketones
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