Cortisol in tissue and systemic level as a contributing factor to the development of metabolic syndrome in severely obese patients

内科学 内分泌学 代谢综合征 脂肪组织 医学 糖皮质激素受体 糖皮质激素 肥胖 背景(考古学) 氢化可的松 生物 古生物学
作者
Petros Constantinopoulos,Marina Michalaki,Αναστασία Κοττόρου,Ioannis Habeos,Agathoklis Psyrogiannis,Fotios Kalfarentzos,Venetsana Kyriazopoulou
出处
期刊:European journal of endocrinology [Bioscientifica]
卷期号:172 (1): 69-78 被引量:30
标识
DOI:10.1530/eje-14-0626
摘要

Context Adrenal and extra-adrenal cortisol production may be involved in the development of metabolic syndrome (MetS). Objective To investigate the activity of the hypothalamic–pituitary–adrenal (HPA) axis and the expression of HSD11B1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptors) α (NR3C1α) and β (NR3C1β) in the liver, subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of severely obese patients with and without MetS. Methods The study included 37 severely obese patients (BMI ≥40 kg/m 2 ), 19 with MetS (MetS+ group) and 18 without (MetS− group), studied before and during bariatric surgery. Before the day of surgery, urinary free cortisol (UFC) and diurnal variation of serum and salivary cortisol were estimated. During surgery, biopsies of the liver, VAT and SAT were obtained. The expression of HSD11B1, NR3C1α and NR3C1β was evaluated by RT-PCR. Results UFC and area under the curve for 24-h profiles of serum and salivary cortisol were lower in the MetS− group. In the MetS− group, mRNA levels of HSD11B1 in liver exhibited a negative correlation with liver NR3C1α (LNR3C1α) and VAT expression of HSD11B1 was lower than the MetS+ group. Conclusions We observed a downregulation of the NR3C1α expression and lower VAT mRNA levels of HSD11B1 in the MetS− group, indicating a lower selective tissue cortisol production and action that could protect these patients from the metabolic consequences of obesity. In the MetS− group, a lower activity of the HPA axis was also detected. Taken together, cortisol in tissue and systematic level might play a role in the development of MetS in severely obese patients.
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