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Guideline for the diagnosis and management of vitiligo

白癜风 医学 指南 皮肤病科 皮密莫司 紫外线疗法 脱色 他克莫司 临床试验 紫外线b 外科 移植 病理 银屑病
作者
David J. Gawkrodger,Anthony Ormerod,Lindsay Shaw,I. Mauri-Sole,Maxine E Whitton,Mike Watts,Alex Anstey,Jane Ingham,Katharine Young
出处
期刊:British Journal of Dermatology [Wiley]
卷期号:159 (5): 1051-1076 被引量:279
标识
DOI:10.1111/j.1365-2133.2008.08881.x
摘要

This detailed and user-friendly guideline for the diagnosis and management of vitiligo in children and adults aims to give high quality clinical advice, based on the best available evidence and expert consensus, taking into account patient choice and clinical expertise. The guideline was devised by a structured process and is intended for use by dermatologists and as a resource for interested parties including patients. Recommendations and levels of evidence have been graded according to the method developed by the Scottish Inter-Collegiate Guidelines Network. Where evidence was lacking, research recommendations were made. The types of vitiligo, process of diagnosis in primary and secondary care, and investigation of vitiligo were assessed. Treatments considered include offering no treatment other than camouflage cosmetics and sunscreens, the use of topical potent or highly potent corticosteroids, of vitamin D analogues, and of topical calcineurin inhibitors, and depigmentation with p-(benzyloxy)phenol. The use of systemic treatment, e.g. corticosteroids, ciclosporin and other immunosuppressive agents was analyzed. Phototherapy was considered, including narrowband ultraviolet B (UVB), psoralen with ultraviolet A (UVA), and khellin with UVA or UVB, along with combinations of topical preparations and various forms of UV. Surgical treatments that were assessed include full-thickness and split skin grafting, mini (punch) grafts, autologous epidermal cell suspensions, and autologous skin equivalents. The effectiveness of cognitive therapy and psychological treatments was considered. Therapeutic algorithms using grades of recommendation and levels of evidence have been produced for children and for adults with vitiligo.
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