石英晶体微天平
纳米颗粒
胶体金
纳米技术
化学
材料科学
壳聚糖
凝结
化学工程
有机化学
心理学
精神科
工程类
吸附
作者
Heike Ehmann,Doris Breitwieser,Sascha Winter,Christian Gspan,Günther Koraimann,Uroš Maver,Marija Sega,Stefan Köstler,Karin Stana‐Kleinschek,Stefan Spirk,Volker Ribitsch
标识
DOI:10.1016/j.carbpol.2014.08.116
摘要
Simultaneous antibacterial and anticoagulant surfaces have been prepared by immobilization of engineered gold nanoparticles onto different kinds of surfaces. The gold nanoparticle core is surrounded by a hemocompatible, anticoagulant polysaccharide, 6-O chitosan sulfate, which serves as reduction and stabilizing agent for the generation of gold nanoparticles in a microwave mediated reaction. The particle suspension shows anticoagulant activity, which is investigated by aPTT and PT testing on citrated blood samples of three patients suffering from congenital or acquired bleeding disorders. The amount of nanoparticles deposited on the surfaces is quantified by a quartz crystal microbalance with dissipation unit. All gold containing surfaces exhibit excellent antimicrobial properties against the chosen model organism, Escherichia coli MG 1655 [R1-16]. Moreover, blood plasma coagulation times of the surfaces are increased after deposition of the engineered nanoparticles as demonstrated by QCM-D.
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