银屑病
生物
表观遗传学
发病机制
疾病
遗传学
后生
生物信息学
免疫学
基因
医学
基因表达
DNA甲基化
病理
作者
Simranjit Singh,Dibyabhaba Pradhan,Poonam Puri,V. Ramesh,Sandeep Aggarwal,Arnab Nayek,Arun K. Jain
出处
期刊:Gene
[Elsevier]
日期:2018-10-01
卷期号:683: 61-71
被引量:66
标识
DOI:10.1016/j.gene.2018.09.042
摘要
Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving interplay between environmental and genetic risk factors as disease initiating event. Enhanced understanding on genetic risk factors, differentially expressed genes, deregulated proteins and pathway-targeted therapeutics have established multiple axis of psoriasis pathogenesis. So far, loci in 424 genes are reported to be associated with psoriasis alongside copy number variations and epigenetic alterations. From clinical perspective, presence of specific genetic trigger(s) in individual psoriasis patient could aid in devising a personalized therapeutic strategy. Therefore, the review presents an updates on reported genomic alterations and their subsequent course of cutaneous inflammations that potentially drive to psoriasis.
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