立体中心
筑地反应
化学
电泳剂
亲核细胞
烷基化
烯丙基重排
对映选择合成
钯
催化作用
转鼓
组合化学
立体化学
不对称诱导
药物化学
有机化学
作者
Barry M. Trost,Johnathan E. Schultz
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2018-12-05
卷期号:51 (01): 1-30
被引量:86
标识
DOI:10.1055/s-0037-1610386
摘要
Over the past 20 years, the asymmetric synthesis of acyclic tetrasubstituted stereocenters by Pd-catalyzed asymmetric allylic alkylation (Pd-AAA) strategies has seen considerable growth. Despite the inherent difficulty in accessing acyclic tetrasubstituted stereocenters, creative approaches toward this problem have resulted in high stereoinduction on both electrophilic and nucleophilic reaction partners. Much of this chemistry has paved the way for unique solutions in Mo-, Ir-, and Rh-AAA, with many complimentary methods arising due to the unique regiochemical outcomes of AAA outside of Pd catalysis. 1 Introduction 2 Stereocontrol on Prochiral Electrophiles 3 Stereocontrol on Prochiral Nucleophiles 4 Temporary Cyclic Pronucleophiles 5 Allylic Alkylation with Other Metals 6 Conclusions and Outlook
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