适体
指数富集配体系统进化
选择(遗传算法)
寡核苷酸
计算机科学
计算生物学
生物
人工智能
DNA
遗传学
核糖核酸
基因
标识
DOI:10.1016/j.bbagen.2018.07.029
摘要
SELEX technique is employed to select aptamers against wide range of targets. The in vitro method of aptamer selection using live cells as the target is referred as cell-SELEX. The review provides a comprehensive description on the development of aptamers through various cell-SELEX methods and list of aptamers identified through this method. In addition, it pinpoints the advantages and limitations of the cell-SELEX process and its variants. The use of aptamers as therapeutic and diagnostic agents is rapidly evolving, selection techniques such as Cell-SELEX could be beneficial in identifying aptamers when the target is in its native conformation and without prior information of the cognate target, thereby bringing the aptamer development one step closer to the clinic. The information in this review can serve as a database for the design and development of futuristic oligonucleotide based diagnostics and therapeutics work.
科研通智能强力驱动
Strongly Powered by AbleSci AI