经络
神经炎症
氧化应激
活性氧
神经保护
细胞生物学
小胶质细胞
化学
脂多糖
生物
药理学
生物化学
炎症
免疫学
木犀草素
类黄酮
抗氧化剂
作者
Pandi He,Shikai Yan,Xin Wen,Shuhan Zhang,Zhigang Liu,Xuebo Liu,Changlai Xiao
摘要
Abstract Oxidative stress takes part in the development of the neurodegenerative disease. Eriodictyol, a flavonoid, commonly presents in citrus fruits, which was well‐known for its various bioactivities. The purpose of this study was to investigate the neuroprotective effects of eriodictyol on lipopolysaccharide (LPS)‐induced neuroinflammation, oxidative stress, synaptic dysfunctions, and the potential mechanisms involved. We found that eriodictyol explicitly restored LPS‐triggered the decrease of cell viability and the mitochondrial potential as well as inflammation responses via mitogen‐activated protein kinases (MAPKs) and nuclear factor κB (NF‐κB) pathways regulated by reactive oxygen species (ROS). Besides, eriodictyol alleviated LPS‐induced oxidative stress via NF‐E2‐Related factor2/Kelch‐like ECH‐associated protein 1 (Nrf2/Keap1) pathway in vivo and in vitro. Furthermore, eriodictyol reduced LPS‐elicited synaptic dysfunctions via increasing the expression of silent information regulator 1 (Sirt1). Overall, eriodictyol protects LPS‐triggered oxidative stress, neuroinflammation, and synaptic dysfunctions partially through MAPKs, NF‐κB mediated by ROS, Sirt1, and Nrf2/Keap1 signal pathways, which further supports that eriodictyol is a potentially nutritional preventive strategy for oxidative stress‐related neurodegenerative diseases.
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