淋巴瘤
伯基特淋巴瘤
生发中心
弥漫性大B细胞淋巴瘤
癌症研究
B细胞淋巴瘤
BCL10
大细胞淋巴瘤
医学
病理
生物
作者
Blanca González-Farré,Joan Enric Ramis-Zaldívar,Julia Salmerón-Villalobos,Olga Balagué,Verónica Celis,Jaime Verdú‐Amorós,Ferran Nadeu,Constantino Sábado,Antonio Ferrández,Marta Garrido,F. García-Bragado,María Dolores de la Maya,José Manuel Vagace,Carlos Panizo,Itziar Astigarraga,Mara Andrés,Elaine S. Jaffe,Elı́as Campo,Itziar Salaverría
出处
期刊:Haematologica
[Ferrata Storti Foundation]
日期:2019-02-07
卷期号:104 (9): 1822-1829
被引量:65
标识
DOI:10.3324/haematol.2018.207928
摘要
Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling those of Burkitt lymphoma but lacks the MYC rearrangement and carries an 11q-arm aberration with proximal gains and telomeric losses. Whether this lymphoma is a distinct category or a particular variant of other recognized entities is controversial. To improve the understanding of Burkitt-like lymphoma with 11q aberration we performed an analysis of copy number alterations and targeted sequencing of a large panel of B-cell lymphoma-related genes in 11 cases. Most patients had localized nodal disease and a favorable outcome after therapy. Histologically, they were high grade B-cell lymphoma, not otherwise specified (8 cases), diffuse large B-cell lymphoma (2 cases) and only one was considered as atypical Burkitt lymphoma. All cases had a germinal center B-cell signature and phenotype with frequent LMO2 expression. The patients with Burkitt-like lymphoma with 11q aberration had frequent gains of 12q12-q21.1 and losses of 6q12.1-q21, and lacked common Burkitt lymphoma or diffuse large B-cell lymphoma alterations. Potential driver mutations were found in 27 genes, particularly involving BTG2, DDX3X, ETS1, EP300, and GNA13. However, ID3, TCF3, or CCND3 mutations were absent in all cases. These results suggest that Burkitt-like lymphoma with 11q aberration is a germinal center-derived lymphoma closer to high-grade B-cell lymphoma or diffuse large B-cell lymphoma than to Burkitt lymphoma.
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