胶溶蛋白
细胞凋亡
前列腺癌
蛋白激酶B
癌症研究
医学
免疫组织化学
细胞生长
下调和上调
前列腺
病理
癌症
肌动蛋白
内科学
生物
细胞生物学
遗传学
基因
生物化学
作者
Tieqiu Li,Xiuqin Hong,Jie Zhao,Yili Teng,Jue Zheng,Hao Chen,Heng‐Gui Chen,Huahua Li
出处
期刊:Biomarkers in Medicine
[Future Medicine]
日期:2016-12-01
卷期号:10 (12): 1251-1260
被引量:18
标识
DOI:10.2217/bmm-2016-0186
摘要
To investigate the role of gelsolin-like actin-capping protein (CapG) in prostate cancer (PCa).CapG expression and its correlation with clinicopathological characters and patient prognosis were analyzed in 76 cases of PCa by immunohistochemistry and qRT-PCR. Then, the influence of CapG downregulation on cell apoptosis and proliferation were assessed.CapG expression in PCa was significantly higher compared with those in matched adjacent noncancerous prostate tissues, and significantly correlated with clinicopathological characters. Survival analysis indicated that CapG could be an independent prognostic factor in PCa. Moreover, CapG depletion significantly affected cellular proliferation and apoptosis by regulating Caspase 6/Caspase 9/Bcl-2/p-Akt/Akt signaling pathway.CapG, as a potential biomarker in PCa, is associated with patient prognosis, cellular apoptosis and proliferation.
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