Longitudinal optical monitoring of blood flow in breast tumors during neoadjuvant chemotherapy

血流 漫反射光学成像 医学 脱氧血红蛋白 化疗 病变 氧饱和度 病理 血红蛋白 核医学 内科学 放射科 氧气 化学 断层摄影术 有机化学
作者
Jeffrey M. Cochran,So Hyun Chung,A Leproux,Wesley B. Baker,David R. Busch,Angela DeMichele,Julia Tchou,Bruce J. Tromberg,Arjun G. Yodh
出处
期刊:Physics in Medicine and Biology [IOP Publishing]
卷期号:62 (12): 4637-4653 被引量:17
标识
DOI:10.1088/1361-6560/aa6cef
摘要

We measure tissue blood flow markers in breast tumors during neoadjuvant chemotherapy and investigate their correlation to pathologic complete response in a pilot longitudinal patient study (n = 4). Tumor blood flow is quantified optically by diffuse correlation spectroscopy (DCS), and tissue optical properties, blood oxygen saturation, and total hemoglobin concentration are derived from concurrent diffuse optical spectroscopic imaging (DOSI). The study represents the first longitudinal DCS measurement of neoadjuvant chemotherapy in humans over the entire course of treatment; it therefore offers a first correlation between DCS flow indices and pathologic complete response. The use of absolute optical properties measured by DOSI facilitates significant improvement of DCS blood flow calculation, which typically assumes optical properties based on literature values. Additionally, the combination of the DCS blood flow index and the tissue oxygen saturation from DOSI permits investigation of tissue oxygen metabolism. Pilot results from four patients suggest that lower blood flow in the lesion-bearing breast is correlated with pathologic complete response. Both absolute lesion blood flow and lesion flow relative to the contralateral breast exhibit potential for characterization of pathological response. This initial demonstration of the combined optical approach for chemotherapy monitoring provides incentive for more comprehensive studies in the future and can help power those investigations.
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