医学
甲状腺球蛋白
甲状腺癌
临床意义
内科学
甲状腺
肿瘤科
疾病
抗体
自身抗体
代理终结点
免疫学
出处
期刊:Current Opinion in Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2015-01-01
卷期号:27 (1): 26-32
被引量:16
标识
DOI:10.1097/cco.0000000000000149
摘要
Purpose of review To provide an overview of the clinical utility of thyroglobulin antibody (TgAb) measurements in the management of differentiated thyroid cancer (DTC), taking into consideration the methodological concerns associated with these measurements. Recent findings In the past 1 to 2 years, clinical studies have added to our understanding of the limitations and pitfalls associated with TgAb assay methods, the association of autoimmune thyroid disease with DTC, the prognostic significance of TgAb positivity and the clinical utility of the trend of TgAb measurements as a surrogate tumor marker. Summary TgAb trends appear to have clinical utility as a surrogate tumor marker in the surveillance of TgAb-positive DTC patients. The prognostic significance of TgAb status (positive/negative) as well as the nature and clinical significance of the association of autoimmune thyroid disease with DTC is less clear.
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