医学
鼻息肉
哮喘
嗜酸性粒细胞
痰
嗜酸性阳离子蛋白
气道阻塞
气道
免疫学
内科学
炎症
胃肠病学
麻醉
病理
肺结核
作者
Lara Bilodeau,Marie‐Ève Boulay,Philippe Prince,Pierre Boisvert,Louis‐Philippe Boulet
出处
期刊:Rhinology
[Rhinology]
日期:2010-12-01
卷期号:48 (4): 420-425
被引量:43
摘要
Nasal polyposis (NP) is associated with a more severe and steroid-resistant asthma.To compare clinical and airway inflammatory features of asthmatics with or without NP.Two groups of asthmatic patients were studied: group 1; n=39, with NP; group 2; n=40, without NP. Asthma control was assessed according to the Asthma Control Scoring System (ACSS). Expiratory flows, induced sputum, and blood eosinophils were also measured.ACSS score was lower (poorer control) in group 1 (meanA+-SEM = 73A+-3%) compared with group 2 (82A+-2%, p=0.01). FEV1 (mean of predicted value A+- SEM) was 81A+-3 for group 1 and 96A+-3 for group 2 (p=0.001), and the FEV1/FVC ratio was lower in group 1 (70A+-2%) compared with group 2 (76A+-1%, p=0.01). Blood and induced sputum eosinophils, as well as fibronectin and eosinophil cationic protein levels, were higher in group 1.Asthmatic subjects with NP have increased airway obstruction, increased inflammatory cells and reduced asthma control compared to those without NP. This may suggest a contribution of nasal polyps to the severity of asthma or a common susceptibility to develop upper and lower airways mucosal inflammation.
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