他克莫司
角质层
脂质体
粒径
分散性
色谱法
渗透
生物医学工程
化学
材料科学
医学
纳米技术
膜
移植
外科
病理
有机化学
物理化学
生物化学
作者
Guiling Li,Chao Fan,Xinru Li,Yating Fan,Xiaoning Wang,Mei Li,Yan Liu
摘要
The main objective of the present work was to prepare and assess dermal delivery of tacrolimus-loaded ethosomes versus classic liposomes. Both delivery systems were characterized for particle size, polydispersity index, and entrapment efficiency (EE), by dynamic laser diffraction and ultrafiltration or dialysis methods, respectively. The results indicated that presence of ethanol in the formulations affected the particle size. In addition, ultrafiltration method was selected to determine EE due to relatively short period as compared with dialysis method. Ethosomes exhibited a significant higher EE and amount of drug in dermis in contrast to classic liposomes suggesting that ethosomes with higher entrapment capacity prompted more amount of tacrolimus to permeate through stratum corneum and reach the target of atopic dermatitis (AD). Physical stability was very well for tacrolimus-loaded ethosomes under storage condition (4 °C). Our results demonstrated that the ethosomal system might be a promising candidate for dermal delivery of tacrolimus for AD.
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