Behavioral changes on amyotrophic lateral sclerosis (ALS): a case of ALS/FTD TDP-43 proteinopathy

The frontotemporal dementia (FTD) is the second most common form of dementia in patients younger than 65 years, and its behavioral variant (bvFTD) is the most prevalent form1,2. During the last years, the overlapping between FTD and amyotrophic lateral sclerosis (ALS) has been frequently recognized, with symptoms of FTD preceding ALS and vice-versa. Herein, we report a case of ALS, which afterwards presented psychotic and behavioral symptoms, whose neuropathological diagnosis was compatible with bvFTD-ALS with TAR DNA-binding protein 43 (TDP-43) [...]