金黄色葡萄球菌
毒力
医学
传输(电信)
耐甲氧西林金黄色葡萄球菌
重症监护医学
甲氧西林
葡萄球菌感染
微生物学
生物
细菌
生物化学
遗传学
电气工程
基因
工程类
作者
Frank R. DeLeo,Michaël Otto,Barry N. Kreiswirth,Henry F. Chambers
出处
期刊:The Lancet
[Elsevier]
日期:2010-03-08
卷期号:375 (9725): 1557-1568
被引量:1443
标识
DOI:10.1016/s0140-6736(09)61999-1
摘要
Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections.
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