重氮甲烷
试剂
原位
化学
环加成
催化作用
氯仿
组合化学
溶剂
爆炸物
有机化学
标识
DOI:10.1002/anie.201501529
摘要
Abstract A novel approach to agrochemically important difluoromethyl‐substituted pyrazoles has been developed based on the elusive reagent CF 2 HCHN 2 , which was synthesized (generated in situ) for the first time and employed in [3+2] cycloaddition reactions with alkynes. The reaction is extremely practical as it is a one‐pot process, does not require a catalyst or the isolation of the potentially toxic and explosive gaseous intermediate, and proceeds in a common solvent, namely chloroform, in air. The reaction is also scalable and allows for the preparation of the target pyrazoles on gram scale.
科研通智能强力驱动
Strongly Powered by AbleSci AI