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原癌基因酪氨酸蛋白激酶Src
磷酸酶
化学
计算生物学
虚拟筛选
生物
对接(动物)
生物化学
体外
癌症研究
信号转导
酶
药物发现
医学
护理部
作者
Yuqing Duan,Ying Ma,Xuejiao Wang,Yuanyuan Jin,Run‐Ling Wang,Wei‐Li Dong,Weiren Xu,Kong De,Li Wang
出处
期刊:Protein and Peptide Letters
[Bentham Science]
日期:2014-04-01
卷期号:21 (6): 556-563
被引量:10
标识
DOI:10.2174/0929866521666131223143913
摘要
Due to the vital role in many cell regulatory processes, such as cell cycle control, survival and apoptosis, as well as growth and neurotransmitter signaling, Src homology 2 (SH2) domain-containing phosphatase 2(Shp2) has attracted considerable attention for developing drugs to treat cancers. In this study, by means of the powerful "core hopping" technique, a novel class of inhibitors was discovered based on the compound II-B08. It was observed by molecular dynamics simulations that these novel inhibitors not only possessed the same function as II-B08 did in inhibiting Shp2, but also had stronger binding to the receptor. It was further validated by the outcomes of their ADME (absorption, distribution, metabolism, and excretion) predictions that the new inhibitors hold high potential to become promising drug candidates for developing novel and powerful drugs for anticancer. Subsequently, in vitro evaluation of promising hits revealed a novel and selective inhibitor of Shp2.
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