Pathological Aggressiveness of Prostatic Carcinomas Related to RNASEL R462Q Allelic Variants

No AccessJournal of UrologyAdult Urology1 Apr 2008Pathological Aggressiveness of Prostatic Carcinomas Related to RNASEL R462Q Allelic Variantsis accompanied byEarly Postoperative Plasma Transforming Growth Factor-β1 is a Strong Predictor of Biochemical Progression After Radical Prostatectomy Benjamin T. Larson, Cristina Magi-Galluzzi, Graham Casey, Sarah J. Plummer, Robert Silverman, and Eric A. Klein Benjamin T. LarsonBenjamin T. Larson Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio , Cristina Magi-GalluzziCristina Magi-Galluzzi Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio , Graham CaseyGraham Casey Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio , Sarah J. PlummerSarah J. Plummer Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio , Robert SilvermanRobert Silverman Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio , and Eric A. KleinEric A. Klein Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio View All Author Informationhttps://doi.org/10.1016/j.juro.2007.11.078AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Allelic variations in the HPC1/RNASEL gene, especially the R462Q single nucleotide polymorphism, have been associated with increased susceptibility to prostate cancer. Prior studies have suggested that HPC1 or R462Q associated tumors present with more aggressive clinical features. We assessed a series of men undergoing radical prostatectomy for clinical and pathological measures of tumor aggressiveness according to the RNASEL R462Q genotype. Materials and Methods: A prospective analysis of 232 men treated for prostate cancer with radical prostatectomy was performed. Disease aggressiveness at diagnosis was assessed by age at disease onset, biopsy Gleason score, clinical T stage and pretreatment prostate specific antigen. Tumor aggressiveness was assessed pathologically by tumor volume, extraprostatic extension, seminal vesicle involvement and lymph node metastasis. Clinical and pathological characteristics were then correlated with RNASEL genotype. Results: Of the 232 men studied 104 (45%) were homozygous WT, 101 (43%) were heterozygous and 27 (12%) were homozygous for the R462Q variant, mirroring the distribution in the general population. No significant differences were seen between genotypes in age at disease onset, pretreatment characteristics or pathological features, as assessed by surgical grade and pathological stage. Tumors homozygous for the R462Q variant were of smaller volume than other genotypes (p = 0.02). 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Google Scholar © 2008 by American Urological AssociationFiguresReferencesRelatedDetailsCited byReinhardt D, Helfand B, Cooper P, Roehl K, Catalona W and Loeb S (2018) Prostate Cancer Risk Alleles are Associated with Prostate Cancer Volume and Prostate SizeJournal of Urology, VOL. 191, NO. 6, (1733-1736), Online publication date: 1-Jun-2014.Related articlesJournal of Urology22 Feb 2008Early Postoperative Plasma Transforming Growth Factor-β1 is a Strong Predictor of Biochemical Progression After Radical Prostatectomy Volume 179Issue 4April 2008Page: 1344-1348 Advertisement Copyright & Permissions© 2008 by American Urological AssociationKeywordsgenetic predisposition to diseasepolymorphismgenotypeprostatic neoplasmsprostatesingle nucleotideMetricsAuthor Information Benjamin T. Larson Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio More articles by this author Cristina Magi-Galluzzi Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio More articles by this author Graham Casey Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Sarah J. Plummer Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio More articles by this author Robert Silverman Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio Financial interest and/or other relationship with Abbott Diagnostics. More articles by this author Eric A. Klein Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio Financial interest and/or other relationship with Abbott Diagnostics. More articles by this author Expand All Advertisement PDF downloadLoading ...