Room‐Temperature Decarboxylative Couplings of α‐Oxocarboxylates with Aryl Halides by Merging Photoredox with Palladium Catalysis

Abstract Enabled by merging iridium photoredox catalysis and palladium catalysis, α‐oxocarboxylate salts can be decarboxylatively coupled with aryl halides to generate aromatic ketones and amides at room temperature. DFT calculations suggest that this reaction proceeds through a Pd 0 –Pd II –Pd III pathway, in which the Pd III intermediate is responsible for reoxidizing Ir II to complete the Ir III –*Ir III –Ir II photoredox cycle.